Drug interactions
Glimepiride + Sulfisoxazole
Severity: Moderate
Glimepiride and Sulfisoxazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfisoxazole can raise sulfonylurea exposure and enhance its hypoglycemic action, with reports of severe hypoglycemia with sulfonamides. Elderly patients and those with renal or hepatic impairment are most at risk.
What this interaction means in plain words
Glimepiride and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C9 metabolism and displacement from plasma protein binding increase free glimepiride concentrations.
What to do
Check blood glucose frequently during co-administration and consider reducing the glimepiride dose. Educate the patient on recognizing hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Sulfisoxazole?
MediHelp rates the interaction as moderate. Glimepiride and Sulfisoxazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfisoxazole can raise sulfonylurea exposure and enhance its hypoglycemic action, with reports of severe hypoglycemia with sulfonamides. Elderly patients and those with renal or hepatic impairment are most at risk.
How serious is the interaction between Glimepiride and Sulfisoxazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose frequently during co-administration and consider reducing the glimepiride dose. Educate the patient on recognizing hypoglycemia.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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