Drug interactions
Glimepiride + Xipamide
Severity: Moderate
Glimepiride and Xipamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Thiazide-like diuretics such as xipamide can raise blood glucose and reduce the effectiveness of antidiabetic drugs. Hypokalemia may also impair insulin secretion.
What this interaction means in plain words
Glimepiride and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Diuretic-induced hypokalemia and reduced insulin sensitivity produce pharmacodynamic antagonism of the hypoglycemic effect.
What to do
Monitor blood glucose and serum potassium, and adjust glimepiride dose if control worsens. Correct hypokalemia promptly.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride
Frequently asked questions
Can I take Glimepiride with Xipamide?
MediHelp rates the interaction as moderate. Glimepiride and Xipamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Thiazide-like diuretics such as xipamide can raise blood glucose and reduce the effectiveness of antidiabetic drugs. Hypokalemia may also impair insulin secretion.
How serious is the interaction between Glimepiride and Xipamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and serum potassium, and adjust glimepiride dose if control worsens. Correct hypokalemia promptly.
What other medicines interact with Glimepiride?
MediHelp also lists interactions of Glimepiride with, for example, Fluconazole, Insulin degludec-liraglutide, Insulin glargine-lixisenatide. The full list is on the Glimepiride page.
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