Drug interactions
Glimepiride-pioglitazone + Ketoprofen
Severity: Moderate
Glimepiride-pioglitazone and Ketoprofen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can potentiate sulfonylurea-induced hypoglycemia. NSAIDs may also cause fluid retention and renal effects, which are relevant with pioglitazone.
What this interaction means in plain words
Glimepiride-pioglitazone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Ketoprofen belongs to Musculoskeletal.
Why it happens
Possible displacement of glimepiride from protein binding and prostaglandin-related effects on insulin secretion and renal function, but the mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping the NSAID and lower the glimepiride dose if needed. Use the lowest effective NSAID dose for the shortest time and watch for edema.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Ketoprofen
- Ketoprofen + Ketorolac Contraindicated
- Ketoprofen + Ketorolac intranasal Contraindicated
- Aceclofenac + Ketoprofen Major
- Acemetacin + Ketoprofen Major
- Acetylsalicylic acid + Ketoprofen Major
- Alteplase + Ketoprofen Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Ketoprofen?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Ketoprofen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can potentiate sulfonylurea-induced hypoglycemia. NSAIDs may also cause fluid retention and renal effects, which are relevant with pioglitazone.
How serious is the interaction between Glimepiride-pioglitazone and Ketoprofen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping the NSAID and lower the glimepiride dose if needed. Use the lowest effective NSAID dose for the shortest time and watch for edema.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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