Drug interactions
Glimepiride-pioglitazone + Linezolid
Severity: Moderate
Glimepiride-pioglitazone and Linezolid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Linezolid has been associated with hypoglycemia in diabetic patients receiving insulin or oral antidiabetic drugs. Episodes may be significant and need treatment.
What this interaction means in plain words
Glimepiride-pioglitazone and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Linezolid belongs to Anti Bacterial.
Why it happens
Linezolid is a weak MAO inhibitor and may affect glucose regulation; the exact mechanism is not established.
What to do
Monitor blood glucose during linezolid therapy and lower the glimepiride dose if hypoglycemia occurs. Counsel the patient on symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Linezolid
- Amoxapine + Linezolid Contraindicated
- Atomoxetine + Linezolid Contraindicated
- Benzphetamine + Linezolid Contraindicated
- Brimonidine + Linezolid Contraindicated
- Bupropion-naltrexone + Linezolid Contraindicated
- Bupropion + Linezolid Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Linezolid?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Linezolid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Linezolid has been associated with hypoglycemia in diabetic patients receiving insulin or oral antidiabetic drugs. Episodes may be significant and need treatment.
How serious is the interaction between Glimepiride-pioglitazone and Linezolid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during linezolid therapy and lower the glimepiride dose if hypoglycemia occurs. Counsel the patient on symptoms.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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