Drug interactions
Glimepiride-pioglitazone + Mifepristone
Severity: Moderate
Glimepiride-pioglitazone and Mifepristone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mifepristone can inhibit CYP2C8 and CYP2C9, raising exposure to pioglitazone and glimepiride. This may increase hypoglycemia risk and pioglitazone adverse effects such as edema.
What this interaction means in plain words
Glimepiride-pioglitazone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Mifepristone belongs to Endocrine.
Why it happens
Inhibition of CYP2C8 (pioglitazone) and CYP2C9 (glimepiride) metabolism by mifepristone.
What to do
Use the lowest effective doses of pioglitazone and glimepiride and monitor blood glucose closely. Watch for edema and hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Mifepristone
- Apixaban + Mifepristone Contraindicated
- Argatroban + Mifepristone Contraindicated
- Cisapride + Mifepristone Contraindicated
- Cortisone + Mifepristone Contraindicated
- Cyclosporin + Mifepristone Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Mifepristone?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Mifepristone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mifepristone can inhibit CYP2C8 and CYP2C9, raising exposure to pioglitazone and glimepiride. This may increase hypoglycemia risk and pioglitazone adverse effects such as edema.
How serious is the interaction between Glimepiride-pioglitazone and Mifepristone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses of pioglitazone and glimepiride and monitor blood glucose closely. Watch for edema and hypoglycemia.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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