Drug interactions
Glimepiride-pioglitazone + Oxaprozin
Severity: Moderate
Glimepiride-pioglitazone and Oxaprozin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxaprozin is an NSAID that is highly protein bound and may enhance the glucose-lowering effect of sulfonylureas such as glimepiride. This can lead to hypoglycemia, particularly in older patients or those with renal impairment.
What this interaction means in plain words
Glimepiride-pioglitazone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Oxaprozin belongs to Musculoskeletal.
Why it happens
Possible displacement of the sulfonylurea from plasma protein binding sites and NSAID effects on glycemia; the exact mechanism is not firmly established.
What to do
Monitor blood glucose when starting or stopping oxaprozin and reduce the glimepiride dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Oxaprozin
- Ketorolac intranasal + Oxaprozin Contraindicated
- Ketorolac + Oxaprozin Contraindicated
- Aceclofenac + Oxaprozin Major
- Acemetacin + Oxaprozin Major
- Acetylsalicylic acid + Oxaprozin Major
- Alteplase + Oxaprozin Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Oxaprozin?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Oxaprozin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxaprozin is an NSAID that is highly protein bound and may enhance the glucose-lowering effect of sulfonylureas such as glimepiride. This can lead to hypoglycemia, particularly in older patients or those with renal impairment.
How serious is the interaction between Glimepiride-pioglitazone and Oxaprozin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping oxaprozin and reduce the glimepiride dose if hypoglycemia occurs. Counsel the patient on hypoglycemia symptoms.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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