Drug interactions
Glimepiride-pioglitazone + Probenecid
Severity: Moderate
Glimepiride-pioglitazone and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid can reduce renal tubular secretion of sulfonylureas and their metabolites, prolonging their effect. This may cause hypoglycemia.
What this interaction means in plain words
Glimepiride-pioglitazone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Probenecid belongs to Genitourinary.
Why it happens
Inhibition of renal tubular organic anion transport reduces sulfonylurea elimination.
What to do
Monitor blood glucose after starting probenecid and reduce the glimepiride dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Probenecid?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid can reduce renal tubular secretion of sulfonylureas and their metabolites, prolonging their effect. This may cause hypoglycemia.
How serious is the interaction between Glimepiride-pioglitazone and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting probenecid and reduce the glimepiride dose if needed.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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