Drug interactions
Glimepiride-pioglitazone + Sparsentan
Severity: Moderate
Glimepiride-pioglitazone and Sparsentan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sparsentan induces CYP2C9 and can reduce exposure to glimepiride. Reduced efficacy and higher blood glucose may follow.
What this interaction means in plain words
Glimepiride-pioglitazone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Sparsentan belongs to Genitourinary.
Why it happens
Sparsentan induces CYP2C9, increasing glimepiride clearance.
What to do
Monitor blood glucose after starting sparsentan and increase glimepiride dose if control worsens.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Sparsentan
- Aliskiren + Sparsentan Contraindicated
- Amlodipine-hydrochlorothiazide-valsartan + Sparsentan Contraindicated
- Amlodipine-olmesartan-hydrochlorothiazide + Sparsentan Contraindicated
- Amlodipine-olmesartan + Sparsentan Contraindicated
- Amlodipine-valsartan + Sparsentan Contraindicated
- Azilsartan-chlorthalidone + Sparsentan Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Sparsentan?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Sparsentan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sparsentan induces CYP2C9 and can reduce exposure to glimepiride. Reduced efficacy and higher blood glucose may follow.
How serious is the interaction between Glimepiride-pioglitazone and Sparsentan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting sparsentan and increase glimepiride dose if control worsens.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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