Drug interactions
Glimepiride-pioglitazone + Sulindac
Severity: Moderate
Glimepiride-pioglitazone and Sulindac: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs such as sulindac may potentiate sulfonylurea effects and cause hypoglycemia, though sulindac is thought to carry less risk than some others. Renal impairment increases the concern.
What this interaction means in plain words
Glimepiride-pioglitazone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Sulindac belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and altered renal clearance; not firmly established.
What to do
Monitor blood glucose when starting or stopping sulindac and reduce glimepiride if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Sulindac
- Ketorolac intranasal + Sulindac Contraindicated
- Ketorolac + Sulindac Contraindicated
- Aceclofenac + Sulindac Major
- Acetylsalicylic acid + Sulindac Major
- Alteplase + Sulindac Major
- Amiloride + Sulindac Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Sulindac?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Sulindac can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs such as sulindac may potentiate sulfonylurea effects and cause hypoglycemia, though sulindac is thought to carry less risk than some others. Renal impairment increases the concern.
How serious is the interaction between Glimepiride-pioglitazone and Sulindac?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping sulindac and reduce glimepiride if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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