Drug interactions
Glimepiride-pioglitazone + Tolfenamic acid
Severity: Moderate
Glimepiride-pioglitazone and Tolfenamic acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tolfenamic acid is an NSAID that may increase the hypoglycemic effect of glimepiride. Hypoglycemia risk is greater in older patients or those with renal impairment.
What this interaction means in plain words
Glimepiride-pioglitazone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Tolfenamic acid belongs to Musculoskeletal.
Why it happens
Possible displacement from plasma protein binding and reduced clearance; not firmly established.
What to do
Monitor blood glucose while taking the NSAID and reduce the glimepiride dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Tolfenamic acid
Frequently asked questions
Can I take Glimepiride-pioglitazone with Tolfenamic acid?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Tolfenamic acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tolfenamic acid is an NSAID that may increase the hypoglycemic effect of glimepiride. Hypoglycemia risk is greater in older patients or those with renal impairment.
How serious is the interaction between Glimepiride-pioglitazone and Tolfenamic acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose while taking the NSAID and reduce the glimepiride dose if hypoglycemia occurs.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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