Drug interactions
Glimepiride-pioglitazone + Tranylcypromine
Severity: Moderate
Glimepiride-pioglitazone and Tranylcypromine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Monoamine oxidase inhibitors such as tranylcypromine can enhance the glucose-lowering effect of sulfonylureas and other antidiabetic drugs. This may lead to unexpected or prolonged hypoglycemia, particularly in patients with variable intake or renal impairment.
What this interaction means in plain words
Glimepiride-pioglitazone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Tranylcypromine belongs to Central Nervous System.
Why it happens
MAO inhibitors may enhance insulin secretion and sensitivity and reduce gluconeogenesis, producing additive hypoglycemic effects; the exact mechanism is not fully established.
What to do
Monitor blood glucose closely when starting, changing or stopping tranylcypromine, and reduce the glimepiride dose if hypoglycemia occurs. Counsel the patient on symptoms of hypoglycemia.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Tranylcypromine
- 5-HTP + Tranylcypromine Contraindicated
- Amitriptyline + Tranylcypromine Contraindicated
- Amoxapine + Tranylcypromine Contraindicated
- Atomoxetine + Tranylcypromine Contraindicated
- Benzphetamine + Tranylcypromine Contraindicated
- Brimonidine + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Tranylcypromine?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Tranylcypromine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Monoamine oxidase inhibitors such as tranylcypromine can enhance the glucose-lowering effect of sulfonylureas and other antidiabetic drugs. This may lead to unexpected or prolonged hypoglycemia, particularly in patients with variable intake or renal impairment.
How serious is the interaction between Glimepiride-pioglitazone and Tranylcypromine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting, changing or stopping tranylcypromine, and reduce the glimepiride dose if hypoglycemia occurs. Counsel the patient on symptoms of hypoglycemia.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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