Drug interactions
Glimepiride-pioglitazone + Verapamil
Severity: Minor
Glimepiride-pioglitazone and Verapamil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Verapamil inhibits CYP3A4 and may modestly raise pioglitazone exposure, as CYP3A4 contributes to its metabolism. Because CYP2C8 is the main pathway, the clinical effect is expected to be small.
What this interaction means in plain words
Glimepiride-pioglitazone and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glimepiride-pioglitazone belongs to Endocrine; Verapamil belongs to Cardiovascular.
Why it happens
Inhibition of CYP3A4 by verapamil may slightly reduce pioglitazone clearance.
What to do
No dose change is generally needed; monitor for edema and glycemic response if verapamil is added.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Frequently asked questions
Can I take Glimepiride-pioglitazone with Verapamil?
MediHelp rates the interaction as minor. Glimepiride-pioglitazone and Verapamil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Verapamil inhibits CYP3A4 and may modestly raise pioglitazone exposure, as CYP3A4 contributes to its metabolism. Because CYP2C8 is the main pathway, the clinical effect is expected to be small.
How serious is the interaction between Glimepiride-pioglitazone and Verapamil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor for edema and glycemic response if verapamil is added.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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