Drug interactions
Glimepiride-pioglitazone + Ziprasidone
Severity: Moderate
Glimepiride-pioglitazone and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ziprasidone can be associated with hyperglycemia and metabolic changes, which may counteract the effect of glimepiride and pioglitazone. Glycemic control may deteriorate, though the effect is generally less than with some other atypical antipsychotics.
What this interaction means in plain words
Glimepiride-pioglitazone and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glimepiride-pioglitazone belongs to Endocrine; Ziprasidone belongs to Central Nervous System.
Why it happens
Pharmacodynamic antagonism through antipsychotic-related impairment of glucose regulation and insulin sensitivity.
What to do
Monitor fasting glucose and HbA1c after starting ziprasidone and adjust antidiabetic therapy as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glimepiride-pioglitazone
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Glimepiride-pioglitazone with Ziprasidone?
MediHelp rates the interaction as moderate. Glimepiride-pioglitazone and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ziprasidone can be associated with hyperglycemia and metabolic changes, which may counteract the effect of glimepiride and pioglitazone. Glycemic control may deteriorate, though the effect is generally less than with some other atypical antipsychotics.
How serious is the interaction between Glimepiride-pioglitazone and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fasting glucose and HbA1c after starting ziprasidone and adjust antidiabetic therapy as needed.
What other medicines interact with Glimepiride-pioglitazone?
MediHelp also lists interactions of Glimepiride-pioglitazone with, for example, Fluconazole, Gemfibrozil, Insulin aspart. The full list is on the Glimepiride-pioglitazone page.
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