Drug interactions
Glipizide-metformin + Ibuprofen
Severity: Minor
Glipizide-metformin and Ibuprofen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ibuprofen may modestly enhance the glucose-lowering effect of glipizide, but clinically significant hypoglycemia is uncommon. NSAIDs can impair renal function, which matters for metformin safety.
What this interaction means in plain words
Glipizide-metformin and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Ibuprofen belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement or CYP2C9 competition; NSAID-related renal prostaglandin inhibition may reduce metformin clearance.
What to do
Monitor blood glucose and renal function with prolonged or high-dose ibuprofen use. Use the lowest effective NSAID dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glipizide-metformin and Ibuprofen, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glipizide-metformin
Other interactions of Ibuprofen
- Ibuprofen + Ketorolac Contraindicated
- Ibuprofen + Ketorolac intranasal Contraindicated
- Acemetacin + Ibuprofen Major
- Alteplase + Ibuprofen Major
- Amiloride + Ibuprofen Major
- Apixaban + Ibuprofen Major
Frequently asked questions
Can I take Glipizide-metformin with Ibuprofen?
MediHelp rates the interaction as minor. Glipizide-metformin and Ibuprofen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Ibuprofen may modestly enhance the glucose-lowering effect of glipizide, but clinically significant hypoglycemia is uncommon. NSAIDs can impair renal function, which matters for metformin safety.
How serious is the interaction between Glipizide-metformin and Ibuprofen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and renal function with prolonged or high-dose ibuprofen use. Use the lowest effective NSAID dose.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
