Drug interactions
Glipizide-metformin + Insulin glulisine
Severity: Moderate
Glipizide-metformin and Insulin glulisine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with a sulfonylurea and metformin increases glucose lowering and raises the risk of hypoglycemia. This combination is used deliberately, but doses often need adjusting.
What this interaction means in plain words
Glipizide-metformin and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Insulin glulisine belongs to Endocrine.
Why it happens
Additive pharmacodynamic glucose-lowering effects through insulin supply (exogenous insulin and sulfonylurea-induced secretion) and reduced hepatic glucose output (metformin).
What to do
Monitor blood glucose frequently when starting or adjusting therapy and reduce the insulin or sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Insulin glulisine
Frequently asked questions
Can I take Glipizide-metformin with Insulin glulisine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Insulin glulisine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with a sulfonylurea and metformin increases glucose lowering and raises the risk of hypoglycemia. This combination is used deliberately, but doses often need adjusting.
How serious is the interaction between Glipizide-metformin and Insulin glulisine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting or adjusting therapy and reduce the insulin or sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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