Drug interactions
Glipizide-metformin + Isocarboxazid
Severity: Moderate
Glipizide-metformin and Isocarboxazid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors such as isocarboxazid can enhance the glucose-lowering effect of sulfonylureas and insulin, leading to hypoglycemia that may be prolonged or severe.
What this interaction means in plain words
Glipizide-metformin and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Isocarboxazid belongs to Central Nervous System.
Why it happens
MAO inhibitors may increase insulin secretion and sensitivity and affect counter-regulatory responses; the exact mechanism is not fully established.
What to do
Monitor blood glucose closely when starting or stopping the MAO inhibitor and reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Isocarboxazid
- 5-HTP + Isocarboxazid Contraindicated
- Amitriptyline + Isocarboxazid Contraindicated
- Amobarbital + Isocarboxazid Contraindicated
- Amoxapine + Isocarboxazid Contraindicated
- Apraclonidine + Isocarboxazid Contraindicated
- Atomoxetine + Isocarboxazid Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Isocarboxazid?
MediHelp rates the interaction as moderate. Glipizide-metformin and Isocarboxazid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors such as isocarboxazid can enhance the glucose-lowering effect of sulfonylureas and insulin, leading to hypoglycemia that may be prolonged or severe.
How serious is the interaction between Glipizide-metformin and Isocarboxazid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or stopping the MAO inhibitor and reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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