Drug interactions
Glipizide-metformin + Ketoconazole
Severity: Major
Glipizide-metformin and Ketoconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ketoconazole can raise glipizide exposure and cause hypoglycemia, which may be severe. Azole antifungals are known to potentiate sulfonylureas.
What this interaction means in plain words
Glipizide-metformin and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glipizide-metformin belongs to Endocrine; Ketoconazole belongs to Anti Fungals.
Why it happens
Ketoconazole inhibits CYP2C9 and other hepatic enzymes, reducing sulfonylurea metabolism.
What to do
Monitor blood glucose closely and reduce the glipizide dose when ketoconazole is started. Counsel the patient on hypoglycemia, and consider an alternative antifungal if possible.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glipizide-metformin
Other interactions of Ketoconazole
- Alfuzosin + Ketoconazole Contraindicated
- Alprazolam + Ketoconazole Contraindicated
- Avanafil + Ketoconazole Contraindicated
- Conivaptan + Ketoconazole Contraindicated
- Dihydroergotamine intranasal + Ketoconazole Contraindicated
- Dihydroergotamine + Ketoconazole Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Ketoconazole?
MediHelp rates the interaction as major. Glipizide-metformin and Ketoconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ketoconazole can raise glipizide exposure and cause hypoglycemia, which may be severe. Azole antifungals are known to potentiate sulfonylureas.
How serious is the interaction between Glipizide-metformin and Ketoconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely and reduce the glipizide dose when ketoconazole is started. Counsel the patient on hypoglycemia, and consider an alternative antifungal if possible.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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