Drug interactions
Glipizide-metformin + Moexipril
Severity: Moderate
Glipizide-metformin and Moexipril: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
ACE inhibitors may increase insulin sensitivity and have been linked to hypoglycemia in patients on sulfonylureas. Reduced renal function from ACE inhibitor therapy can also increase metformin accumulation and the risk of lactic acidosis.
What this interaction means in plain words
Glipizide-metformin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Moexipril belongs to Cardiovascular.
Why it happens
ACE inhibition enhances insulin sensitivity via bradykinin, and renal hemodynamic changes may reduce metformin clearance.
What to do
Monitor blood glucose when starting the ACE inhibitor and check renal function periodically; adjust or stop metformin if renal function deteriorates.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Moexipril
- Aliskiren + Moexipril Contraindicated
- Moexipril + Protein a column Contraindicated
- Moexipril + Sacubitril / valsartan Contraindicated
- Moexipril + Sacubitril-valsartan Contraindicated
- Amifostine + Moexipril Major
- Amiloride + Moexipril Major
Frequently asked questions
Can I take Glipizide-metformin with Moexipril?
MediHelp rates the interaction as moderate. Glipizide-metformin and Moexipril can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. ACE inhibitors may increase insulin sensitivity and have been linked to hypoglycemia in patients on sulfonylureas. Reduced renal function from ACE inhibitor therapy can also increase metformin accumulation and the risk of lactic acidosis.
How serious is the interaction between Glipizide-metformin and Moexipril?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting the ACE inhibitor and check renal function periodically; adjust or stop metformin if renal function deteriorates.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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