Drug interactions
Glipizide-metformin + Naproxen
Severity: Minor
Glipizide-metformin and Naproxen: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may enhance sulfonylurea hypoglycemia, and naproxen can reduce renal function, raising metformin accumulation risk in susceptible patients. Clinically significant effects are uncommon.
What this interaction means in plain words
Glipizide-metformin and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Naproxen belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement and prostaglandin-mediated renal effects; mechanism not firmly established.
What to do
Monitor blood glucose when naproxen is started and check renal function in patients with kidney impairment or dehydration.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Naproxen
- Ketorolac intranasal + Naproxen Contraindicated
- Ketorolac + Naproxen Contraindicated
- Aceclofenac + Naproxen Major
- Acemetacin + Naproxen Major
- Acetylsalicylic acid + Naproxen Major
- Alteplase + Naproxen Major
Frequently asked questions
Can I take Glipizide-metformin with Naproxen?
MediHelp rates the interaction as minor. Glipizide-metformin and Naproxen have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may enhance sulfonylurea hypoglycemia, and naproxen can reduce renal function, raising metformin accumulation risk in susceptible patients. Clinically significant effects are uncommon.
How serious is the interaction between Glipizide-metformin and Naproxen?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when naproxen is started and check renal function in patients with kidney impairment or dehydration.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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