Drug interactions
Glipizide-metformin + Nilotinib
Severity: Moderate
Glipizide-metformin and Nilotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nilotinib has been associated with changes in blood glucose, most often hyperglycemia, which may offset the effect of glucose-lowering therapy. Diabetic patients may therefore see worse glycemic control after starting nilotinib.
What this interaction means in plain words
Glipizide-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Nilotinib belongs to Oncology.
Why it happens
Nilotinib can independently alter glucose homeostasis, producing pharmacodynamic opposition to antidiabetic drugs; the exact mechanism is not well established.
What to do
Check blood glucose regularly after nilotinib is started or stopped. Adjust the glipizide-metformin dose if glycemic control changes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Nilotinib
- Amiodarone + Nilotinib Contraindicated
- Arsenic trioxide + Nilotinib Contraindicated
- Disopyramide + Nilotinib Contraindicated
- Dofetilide + Nilotinib Contraindicated
- Dronedarone + Nilotinib Contraindicated
- Droperidol + Nilotinib Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Nilotinib?
MediHelp rates the interaction as moderate. Glipizide-metformin and Nilotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nilotinib has been associated with changes in blood glucose, most often hyperglycemia, which may offset the effect of glucose-lowering therapy. Diabetic patients may therefore see worse glycemic control after starting nilotinib.
How serious is the interaction between Glipizide-metformin and Nilotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose regularly after nilotinib is started or stopped. Adjust the glipizide-metformin dose if glycemic control changes.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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