Drug interactions
Glipizide-metformin + Ofloxacin
Severity: Moderate
Glipizide-metformin and Ofloxacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Fluoroquinolones can cause both severe hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, especially sulfonylureas. Older and renally impaired patients are at greater risk.
What this interaction means in plain words
Glipizide-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Ofloxacin belongs to Anti Bacterial.
Why it happens
Fluoroquinolones can stimulate pancreatic insulin release by blocking beta-cell potassium channels, adding to sulfonylurea action; the cause of hyperglycemia is less clear.
What to do
Monitor blood glucose during the antibiotic course and educate the patient about hypoglycemia symptoms. Stop the fluoroquinolone and treat if significant dysglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Ofloxacin
- Ofloxacin + Thioridazine Contraindicated
- Adagrasib + Ofloxacin Major
- Amiodarone + Ofloxacin Major
- Amisulpride + Ofloxacin Major
- Anagrelide + Ofloxacin Major
- Arsenic trioxide + Ofloxacin Major
Frequently asked questions
Can I take Glipizide-metformin with Ofloxacin?
MediHelp rates the interaction as moderate. Glipizide-metformin and Ofloxacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Fluoroquinolones can cause both severe hypoglycemia and hyperglycemia in patients taking antidiabetic drugs, especially sulfonylureas. Older and renally impaired patients are at greater risk.
How serious is the interaction between Glipizide-metformin and Ofloxacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during the antibiotic course and educate the patient about hypoglycemia symptoms. Stop the fluoroquinolone and treat if significant dysglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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