Drug interactions
Glipizide-metformin + Pasireotide
Severity: Major
Glipizide-metformin and Pasireotide: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pasireotide suppresses insulin secretion and incretin release and frequently causes hyperglycemia. This directly opposes glipizide and metformin.
What this interaction means in plain words
Glipizide-metformin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Glipizide-metformin belongs to Endocrine; Pasireotide belongs to Endocrine.
Why it happens
Somatostatin receptor agonism reduces insulin and incretin secretion, causing pharmacodynamic antagonism.
What to do
Measure glucose before starting pasireotide and monitor frequently thereafter. Intensify antidiabetic therapy, often with additional agents or insulin, as needed.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Glipizide-metformin
Other interactions of Pasireotide
- Dronedarone + Pasireotide Contraindicated
- Pasireotide + Pimozide Contraindicated
- Amiodarone + Pasireotide Major
- Amisulpride + Pasireotide Major
- Amitriptyline + Pasireotide Major
- Anagrelide + Pasireotide Major
Frequently asked questions
Can I take Glipizide-metformin with Pasireotide?
MediHelp rates the interaction as major. Glipizide-metformin and Pasireotide can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Pasireotide suppresses insulin secretion and incretin release and frequently causes hyperglycemia. This directly opposes glipizide and metformin.
How serious is the interaction between Glipizide-metformin and Pasireotide?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Measure glucose before starting pasireotide and monitor frequently thereafter. Intensify antidiabetic therapy, often with additional agents or insulin, as needed.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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