Drug interactions
Glipizide-metformin + Phenelzine
Severity: Moderate
Glipizide-metformin and Phenelzine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors can lower blood glucose and may enhance the hypoglycemic effect of sulfonylureas such as glipizide. Severe hypoglycemia is possible.
What this interaction means in plain words
Glipizide-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Phenelzine belongs to Central Nervous System.
Why it happens
MAO inhibitors may enhance insulin secretion or sensitivity, causing additive glucose lowering; the mechanism is not fully established.
What to do
Monitor blood glucose when phenelzine is started or stopped. Reduce the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Phenelzine
- 5-HTP + Phenelzine Contraindicated
- Amitriptyline + Phenelzine Contraindicated
- Amoxapine + Phenelzine Contraindicated
- Atomoxetine + Phenelzine Contraindicated
- Benzphetamine + Phenelzine Contraindicated
- Brimonidine + Phenelzine Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Phenelzine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Phenelzine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors can lower blood glucose and may enhance the hypoglycemic effect of sulfonylureas such as glipizide. Severe hypoglycemia is possible.
How serious is the interaction between Glipizide-metformin and Phenelzine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when phenelzine is started or stopped. Reduce the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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