Drug interactions
Glipizide-metformin + Prednisolone
Severity: Moderate
Glipizide-metformin and Prednisolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Systemic prednisolone raises blood glucose and can offset the effect of glipizide and metformin. Hyperglycemia is most pronounced with higher doses and longer courses.
What this interaction means in plain words
Glipizide-metformin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Prednisolone belongs to Endocrine.
Why it happens
Glucocorticoids increase hepatic gluconeogenesis and induce insulin resistance.
What to do
Increase blood glucose monitoring during steroid therapy and adjust antidiabetic doses, then reduce them again when the steroid is tapered.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Prednisolone
- Bcg vaccine live + Prednisolone Contraindicated
- Measles mumps and rubella vaccine live + Prednisolone Contraindicated
- Measles mumps rubella and varicella vaccine live + Prednisolone Contraindicated
- Measles vaccine + Prednisolone Contraindicated
- Mifepristone + Prednisolone Contraindicated
- Prednisolone + Radium-223 dichloride Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Prednisolone?
MediHelp rates the interaction as moderate. Glipizide-metformin and Prednisolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Systemic prednisolone raises blood glucose and can offset the effect of glipizide and metformin. Hyperglycemia is most pronounced with higher doses and longer courses.
How serious is the interaction between Glipizide-metformin and Prednisolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Increase blood glucose monitoring during steroid therapy and adjust antidiabetic doses, then reduce them again when the steroid is tapered.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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