Drug interactions
Glipizide-metformin + Promethazine
Severity: Minor
Glipizide-metformin and Promethazine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Promethazine, a phenothiazine antihistamine, may raise blood glucose and reduce antidiabetic effect. The effect is generally modest with short-term use.
What this interaction means in plain words
Glipizide-metformin and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Promethazine belongs to Respiratory.
Why it happens
Phenothiazine effects on insulin release and sensitivity produce mild pharmacodynamic antagonism.
What to do
Monitor blood glucose if promethazine is used repeatedly or over a prolonged period. Adjust antidiabetic therapy if control worsens.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Promethazine
- Ibutilide + Promethazine Contraindicated
- Pimozide + Promethazine Contraindicated
- Promethazine + Thioridazine Contraindicated
- Alfentanil + Promethazine Major
- Amiodarone + Promethazine Major
- Amisulpride + Promethazine Major
Frequently asked questions
Can I take Glipizide-metformin with Promethazine?
MediHelp rates the interaction as minor. Glipizide-metformin and Promethazine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Promethazine, a phenothiazine antihistamine, may raise blood glucose and reduce antidiabetic effect. The effect is generally modest with short-term use.
How serious is the interaction between Glipizide-metformin and Promethazine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if promethazine is used repeatedly or over a prolonged period. Adjust antidiabetic therapy if control worsens.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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