Drug interactions
Glipizide-metformin + Quinine
Severity: Moderate
Glipizide-metformin and Quinine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metformin and quinine are both cationic drugs eliminated by renal tubular secretion, and they may compete for transporters. This can modestly raise quinine or metformin exposure. Quinine itself can also cause hypoglycemia, which may add to the effect of glipizide.
What this interaction means in plain words
Glipizide-metformin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Quinine belongs to Anti Parasitic.
Why it happens
Competition for renal tubular cation transporters (OCT2/MATE), plus additive hypoglycemic effect of quinine through insulin secretion stimulation.
What to do
Monitor blood glucose during quinine therapy and watch for quinine adverse effects such as cinchonism. Adjust the sulfonylurea dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Quinine
- Arsenic trioxide + Quinine Contraindicated
- Dofetilide + Quinine Contraindicated
- Dronedarone + Quinine Contraindicated
- Ibutilide + Quinine Contraindicated
- Mefloquine + Quinine Contraindicated
- Nilotinib + Quinine Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Quinine?
MediHelp rates the interaction as moderate. Glipizide-metformin and Quinine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Metformin and quinine are both cationic drugs eliminated by renal tubular secretion, and they may compete for transporters. This can modestly raise quinine or metformin exposure. Quinine itself can also cause hypoglycemia, which may add to the effect of glipizide.
How serious is the interaction between Glipizide-metformin and Quinine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during quinine therapy and watch for quinine adverse effects such as cinchonism. Adjust the sulfonylurea dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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