Drug interactions
Glipizide-metformin + Rifabutin
Severity: Moderate
Glipizide-metformin and Rifabutin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Rifabutin induces hepatic enzymes and can speed up glipizide metabolism, lowering its exposure. This may weaken glycemic control, and hypoglycemia risk may rise again when rifabutin is stopped.
What this interaction means in plain words
Glipizide-metformin and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Rifabutin belongs to Anti Bacterial.
Why it happens
Rifabutin induces CYP enzymes, including CYP2C9, increasing glipizide clearance.
What to do
Monitor blood glucose when rifabutin is started or stopped and increase the glipizide dose if control worsens. Reassess the dose after rifabutin withdrawal.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Rifabutin
- Cabotegravir + Rifabutin Contraindicated
- Lorlatinib + Rifabutin Contraindicated
- Rifabutin + Voriconazole Contraindicated
- Apixaban + Rifabutin Major
- Axitinib + Rifabutin Major
- Brexpiprazole + Rifabutin Major
Frequently asked questions
Can I take Glipizide-metformin with Rifabutin?
MediHelp rates the interaction as moderate. Glipizide-metformin and Rifabutin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Rifabutin induces hepatic enzymes and can speed up glipizide metabolism, lowering its exposure. This may weaken glycemic control, and hypoglycemia risk may rise again when rifabutin is stopped.
How serious is the interaction between Glipizide-metformin and Rifabutin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when rifabutin is started or stopped and increase the glipizide dose if control worsens. Reassess the dose after rifabutin withdrawal.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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