Drug interactions
Glipizide-metformin + Selegiline
Severity: Moderate
Glipizide-metformin and Selegiline: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
MAO inhibitors may potentiate the hypoglycemic effect of antidiabetic agents. Selegiline added to glipizide-metformin may increase the risk of low blood glucose.
What this interaction means in plain words
Glipizide-metformin and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Selegiline belongs to Central Nervous System.
Why it happens
The mechanism is not clearly established; MAO inhibition may enhance insulin secretion or sensitivity.
What to do
Monitor blood glucose closely when selegiline is added or removed. Lower the glipizide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Selegiline
- Amitriptyline + Selegiline Contraindicated
- Amoxapine + Selegiline Contraindicated
- Atomoxetine + Selegiline Contraindicated
- Benzphetamine + Selegiline Contraindicated
- Brimonidine + Selegiline Contraindicated
- Buprenorphine long-acting + Selegiline Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Selegiline?
MediHelp rates the interaction as moderate. Glipizide-metformin and Selegiline can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. MAO inhibitors may potentiate the hypoglycemic effect of antidiabetic agents. Selegiline added to glipizide-metformin may increase the risk of low blood glucose.
How serious is the interaction between Glipizide-metformin and Selegiline?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when selegiline is added or removed. Lower the glipizide dose if hypoglycemia develops.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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