Drug interactions
Glipizide-metformin + Tolmetin
Severity: Minor
Glipizide-metformin and Tolmetin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may potentiate the hypoglycemic effect of sulfonylureas like glipizide. Tolmetin could raise hypoglycemia risk, although documentation is limited.
What this interaction means in plain words
Glipizide-metformin and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Glipizide-metformin belongs to Endocrine; Tolmetin belongs to Musculoskeletal.
Why it happens
Possible protein-binding displacement or effects on prostaglandin-mediated insulin secretion; not firmly established.
What to do
Monitor blood glucose when tolmetin is started or stopped. Adjust the glipizide dose if hypoglycemia occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glipizide-metformin
Other interactions of Tolmetin
- Ketorolac intranasal + Tolmetin Contraindicated
- Ketorolac + Tolmetin Contraindicated
- Aceclofenac + Tolmetin Major
- Acemetacin + Tolmetin Major
- Alteplase + Tolmetin Major
- Amlodipine-hydrochlorothiazide-valsartan + Tolmetin Major
Frequently asked questions
Can I take Glipizide-metformin with Tolmetin?
MediHelp rates the interaction as minor. Glipizide-metformin and Tolmetin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs may potentiate the hypoglycemic effect of sulfonylureas like glipizide. Tolmetin could raise hypoglycemia risk, although documentation is limited.
How serious is the interaction between Glipizide-metformin and Tolmetin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when tolmetin is started or stopped. Adjust the glipizide dose if hypoglycemia occurs.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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