Drug interactions
Glipizide-metformin + Triamterene
Severity: Moderate
Glipizide-metformin and Triamterene: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Triamterene is a cationic drug secreted by renal tubular transporters and may compete with metformin, raising metformin exposure. Triamterene has also been reported to increase metformin levels in pharmacokinetic data, which could raise the risk of lactic acidosis in patients with reduced renal function.
What this interaction means in plain words
Glipizide-metformin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Triamterene belongs to Cardiovascular.
Why it happens
Competition for renal tubular secretion via OCT2/MATE transporters, reducing metformin clearance.
What to do
Monitor renal function and glycemic control, and consider reducing the metformin dose if renal function is impaired. Counsel patients to report symptoms of lactic acidosis.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Triamterene
- Amiloride + Triamterene Contraindicated
- Eplerenone + Triamterene Contraindicated
- Potassium citrate / citric acid + Triamterene Contraindicated
- Potassium citrate + Triamterene Contraindicated
- Spironolactone + Triamterene Contraindicated
- Aceclofenac + Triamterene Major
Frequently asked questions
Can I take Glipizide-metformin with Triamterene?
MediHelp rates the interaction as moderate. Glipizide-metformin and Triamterene can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Triamterene is a cationic drug secreted by renal tubular transporters and may compete with metformin, raising metformin exposure. Triamterene has also been reported to increase metformin levels in pharmacokinetic data, which could raise the risk of lactic acidosis in patients with reduced renal function.
How serious is the interaction between Glipizide-metformin and Triamterene?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and glycemic control, and consider reducing the metformin dose if renal function is impaired. Counsel patients to report symptoms of lactic acidosis.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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