Drug interactions
Glipizide-metformin + Vandetanib
Severity: Moderate
Glipizide-metformin and Vandetanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Vandetanib inhibits OCT2, a transporter involved in renal metformin secretion, so metformin levels may increase. This may raise the risk of metformin adverse effects including lactic acidosis.
What this interaction means in plain words
Glipizide-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glipizide-metformin belongs to Endocrine; Vandetanib belongs to Oncology.
Why it happens
Vandetanib inhibits OCT2-mediated renal tubular secretion of metformin.
What to do
Monitor renal function and for metformin toxicity, and consider reducing the metformin dose if adverse effects arise.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glipizide-metformin
Other interactions of Vandetanib
- Amiodarone + Vandetanib Contraindicated
- Amisulpride + Vandetanib Contraindicated
- Amitriptyline + Vandetanib Contraindicated
- Anagrelide + Vandetanib Contraindicated
- Asenapine + Vandetanib Contraindicated
- Chloroquine + Vandetanib Contraindicated
Frequently asked questions
Can I take Glipizide-metformin with Vandetanib?
MediHelp rates the interaction as moderate. Glipizide-metformin and Vandetanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Vandetanib inhibits OCT2, a transporter involved in renal metformin secretion, so metformin levels may increase. This may raise the risk of metformin adverse effects including lactic acidosis.
How serious is the interaction between Glipizide-metformin and Vandetanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for metformin toxicity, and consider reducing the metformin dose if adverse effects arise.
What other medicines interact with Glipizide-metformin?
MediHelp also lists interactions of Glipizide-metformin with, for example, Contrast media, Diatrizoate meglumine / diatrizoate, Diatrizoate. The full list is on the Glipizide-metformin page.
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