Drug interactions
Glucagon intranasal + Indomethacin
Severity: Moderate
Glucagon intranasal and Indomethacin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Indomethacin has been reported to blunt the glycemic response to glucagon, mainly in the context of insulinoma testing, and the effect may even be paradoxical. This could reduce the reliability of glucagon as a rescue treatment for severe hypoglycemia.
What this interaction means in plain words
Glucagon intranasal and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not well established; prostaglandin-related effects on glucagon-induced glucose release have been suggested.
What to do
Check blood glucose after glucagon administration in patients taking indomethacin and give oral or intravenous glucose if the response is inadequate. Make sure caregivers know to seek emergency care if recovery is delayed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Indomethacin
- Indomethacin + Ketorolac Contraindicated
- Indomethacin + Ketorolac intranasal Contraindicated
- Aceclofenac + Indomethacin Major
- Acemetacin + Indomethacin Major
- Acetylsalicylic acid + Indomethacin Major
- Alteplase + Indomethacin Major
Frequently asked questions
Can I take Glucagon intranasal with Indomethacin?
MediHelp rates the interaction as moderate. Glucagon intranasal and Indomethacin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Indomethacin has been reported to blunt the glycemic response to glucagon, mainly in the context of insulinoma testing, and the effect may even be paradoxical. This could reduce the reliability of glucagon as a rescue treatment for severe hypoglycemia.
How serious is the interaction between Glucagon intranasal and Indomethacin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check blood glucose after glucagon administration in patients taking indomethacin and give oral or intravenous glucose if the response is inadequate. Make sure caregivers know to seek emergency care if recovery is delayed.
What other medicines interact with Indomethacin?
MediHelp also lists interactions of Indomethacin with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Indomethacin page.
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