Drug interactions
Glyburide + Gymnema
Severity: Moderate
Glyburide and Gymnema: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gymnema sylvestre has glucose-lowering activity and may add to the effect of glyburide, increasing the chance of hypoglycemia. Product content varies and the clinical data are limited.
What this interaction means in plain words
Glyburide and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive hypoglycemic effect, possibly through reduced intestinal glucose absorption and increased insulin secretion.
What to do
Monitor blood glucose closely if the patient uses gymnema, and reduce the glyburide dose if hypoglycemia occurs. Advise against starting herbal glucose-lowering products without review.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Gymnema?
MediHelp rates the interaction as moderate. Glyburide and Gymnema can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gymnema sylvestre has glucose-lowering activity and may add to the effect of glyburide, increasing the chance of hypoglycemia. Product content varies and the clinical data are limited.
How serious is the interaction between Glyburide and Gymnema?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely if the patient uses gymnema, and reduce the glyburide dose if hypoglycemia occurs. Advise against starting herbal glucose-lowering products without review.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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