Drug interactions
Glyburide + Insulin aspart-insulin aspart protamine
Severity: Moderate
Glyburide and Insulin aspart-insulin aspart protamine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Glyburide with insulin gives additive glucose lowering and increases the risk of hypoglycemia, which may be prolonged, especially with renal impairment.
What this interaction means in plain words
Glyburide and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Insulin aspart-insulin aspart protamine belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect of sulfonylurea-stimulated insulin secretion and exogenous insulin.
What to do
Monitor glucose closely and reduce the dose of either agent if hypoglycemia occurs. Teach hypoglycemia recognition and treatment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin aspart-insulin aspart protamine
- Ethanol + Insulin aspart-insulin aspart protamine Major
- Insulin aspart-insulin aspart protamine + Pentamidine Major
- Insulin aspart-insulin aspart protamine + Pioglitazone Major
- Insulin aspart-insulin aspart protamine + Rosiglitazone Major
- Acarbose + Insulin aspart-insulin aspart protamine Moderate
- Albiglutide + Insulin aspart-insulin aspart protamine Moderate
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Insulin aspart-insulin aspart protamine?
MediHelp rates the interaction as moderate. Glyburide and Insulin aspart-insulin aspart protamine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Glyburide with insulin gives additive glucose lowering and increases the risk of hypoglycemia, which may be prolonged, especially with renal impairment.
How serious is the interaction between Glyburide and Insulin aspart-insulin aspart protamine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor glucose closely and reduce the dose of either agent if hypoglycemia occurs. Teach hypoglycemia recognition and treatment.
What other medicines interact with Insulin aspart-insulin aspart protamine?
MediHelp also lists interactions of Insulin aspart-insulin aspart protamine with, for example, Ethanol, Pentamidine, Pioglitazone. The full list is on the Insulin aspart-insulin aspart protamine page.
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