Drug interactions
Glyburide + Insulin aspart
Severity: Moderate
Glyburide and Insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents lower blood glucose, and the combination raises the risk of hypoglycemia. Glyburide has a long duration and active metabolites, so hypoglycemia may be prolonged, especially in renal impairment or older patients.
What this interaction means in plain words
Glyburide and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Insulin aspart belongs to Endocrine.
Why it happens
Additive glucose lowering from exogenous insulin and sulfonylurea-stimulated endogenous insulin secretion.
What to do
Monitor blood glucose frequently and reduce the glyburide or insulin dose if hypoglycemia occurs. Consider a shorter-acting sulfonylurea in older or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide and Insulin aspart, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Insulin aspart
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Insulin aspart?
MediHelp rates the interaction as moderate. Glyburide and Insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both agents lower blood glucose, and the combination raises the risk of hypoglycemia. Glyburide has a long duration and active metabolites, so hypoglycemia may be prolonged, especially in renal impairment or older patients.
How serious is the interaction between Glyburide and Insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently and reduce the glyburide or insulin dose if hypoglycemia occurs. Consider a shorter-acting sulfonylurea in older or renally impaired patients.
What other medicines interact with Insulin aspart?
MediHelp also lists interactions of Insulin aspart with, for example, Alogliptin-pioglitazone, Ethanol, Glimepiride-pioglitazone. The full list is on the Insulin aspart page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
