Drug interactions
Glyburide + Insulin degludec / insulin aspart
Severity: Moderate
Glyburide and Insulin degludec / insulin aspart: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Insulin and sulfonylureas have additive glucose-lowering effects, so combining them increases the risk of hypoglycemia. The combination is often used deliberately but requires dose coordination.
What this interaction means in plain words
Glyburide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive pharmacodynamic glucose-lowering effects of exogenous insulin and sulfonylurea-stimulated insulin secretion.
What to do
Monitor blood glucose frequently when starting, changing or stopping either agent and reduce the dose of one or both if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Insulin degludec / insulin aspart?
MediHelp rates the interaction as moderate. Glyburide and Insulin degludec / insulin aspart can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Insulin and sulfonylureas have additive glucose-lowering effects, so combining them increases the risk of hypoglycemia. The combination is often used deliberately but requires dose coordination.
How serious is the interaction between Glyburide and Insulin degludec / insulin aspart?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose frequently when starting, changing or stopping either agent and reduce the dose of one or both if hypoglycemia occurs.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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