Drug interactions
Glyburide + Insulin neutral human
Severity: Moderate
Glyburide and Insulin neutral human: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining insulin with a sulfonylurea produces additive glucose lowering and raises the risk of hypoglycemia, which can be prolonged with glyburide, especially in older patients or those with renal impairment. The combination is often used deliberately but needs dose review.
What this interaction means in plain words
Glyburide and Insulin neutral human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Glyburide belongs to Endocrine; Insulin neutral human belongs to Endocrine.
Why it happens
Additive pharmacodynamic effect: exogenous insulin plus sulfonylurea-stimulated endogenous insulin secretion.
What to do
Monitor blood glucose closely when starting or adjusting either drug and reduce the insulin or glyburide dose if hypoglycemia occurs. Consider a shorter-acting sulfonylurea in older or renally impaired patients.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Insulin neutral human
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Insulin neutral human?
MediHelp rates the interaction as moderate. Glyburide and Insulin neutral human can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining insulin with a sulfonylurea produces additive glucose lowering and raises the risk of hypoglycemia, which can be prolonged with glyburide, especially in older patients or those with renal impairment. The combination is often used deliberately but needs dose review.
How serious is the interaction between Glyburide and Insulin neutral human?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose closely when starting or adjusting either drug and reduce the insulin or glyburide dose if hypoglycemia occurs. Consider a shorter-acting sulfonylurea in older or renally impaired patients.
What other medicines interact with Insulin neutral human?
MediHelp also lists interactions of Insulin neutral human with, for example, Chlorpropamide, Ethanol, Mecasermin. The full list is on the Insulin neutral human page.
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