Drug interactions
Glyburide + Lofepramine
Severity: Minor
Glyburide and Lofepramine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants such as lofepramine have occasionally been associated with altered glycemic control and may mask adrenergic hypoglycemia symptoms in patients taking sulfonylureas. The effect is inconsistent and usually modest.
What this interaction means in plain words
Glyburide and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive glucose lowering; the mechanism is not firmly established.
What to do
Monitor blood glucose when lofepramine is started or stopped in a patient on glyburide. Counsel the patient about hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Glyburide and Lofepramine, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Lofepramine?
MediHelp rates the interaction as minor. Glyburide and Lofepramine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants such as lofepramine have occasionally been associated with altered glycemic control and may mask adrenergic hypoglycemia symptoms in patients taking sulfonylureas. The effect is inconsistent and usually modest.
How serious is the interaction between Glyburide and Lofepramine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when lofepramine is started or stopped in a patient on glyburide. Counsel the patient about hypoglycemia symptoms.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
