Drug interactions
Glyburide + Meclofenamate
Severity: Moderate
Glyburide and Meclofenamate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can enhance the glucose-lowering effect of sulfonylureas, increasing the possibility of hypoglycemia. The effect is variable and usually modest, but it is relevant in older patients or those with renal impairment.
What this interaction means in plain words
Glyburide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Possible displacement from protein binding and prostaglandin effects on insulin secretion; mechanism not firmly established.
What to do
Monitor blood glucose when starting or stopping meclofenamate and teach patients the symptoms of hypoglycemia. Lower the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Meclofenamate?
MediHelp rates the interaction as moderate. Glyburide and Meclofenamate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can enhance the glucose-lowering effect of sulfonylureas, increasing the possibility of hypoglycemia. The effect is variable and usually modest, but it is relevant in older patients or those with renal impairment.
How serious is the interaction between Glyburide and Meclofenamate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping meclofenamate and teach patients the symptoms of hypoglycemia. Lower the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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