Drug interactions
Glyburide + Miconazole vaginal
Severity: Moderate
Glyburide and Miconazole vaginal: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole inhibits CYP2C9 and CYP3A4, and vaginal use can produce measurable systemic levels. This may raise glyburide exposure and increase the risk of hypoglycemia, as reported with other azole antifungals.
What this interaction means in plain words
Glyburide and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of CYP2C9 and CYP3A4-mediated glyburide metabolism by absorbed miconazole.
What to do
Monitor blood glucose during and after the miconazole course and warn the patient about hypoglycemia symptoms. Reduce the glyburide dose if glucose falls.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Miconazole vaginal?
MediHelp rates the interaction as moderate. Glyburide and Miconazole vaginal can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Miconazole inhibits CYP2C9 and CYP3A4, and vaginal use can produce measurable systemic levels. This may raise glyburide exposure and increase the risk of hypoglycemia, as reported with other azole antifungals.
How serious is the interaction between Glyburide and Miconazole vaginal?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during and after the miconazole course and warn the patient about hypoglycemia symptoms. Reduce the glyburide dose if glucose falls.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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