Drug interactions
Glyburide + Nicardipine
Severity: Moderate
Glyburide and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nicardipine inhibits CYP2C9 in vitro and may increase glyburide exposure. This could enhance the glucose-lowering effect and cause hypoglycemia, though clinical data are limited.
What this interaction means in plain words
Glyburide and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Nicardipine inhibits CYP2C9 metabolism of glyburide.
What to do
Monitor blood glucose when nicardipine is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Frequently asked questions
Can I take Glyburide with Nicardipine?
MediHelp rates the interaction as moderate. Glyburide and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nicardipine inhibits CYP2C9 in vitro and may increase glyburide exposure. This could enhance the glucose-lowering effect and cause hypoglycemia, though clinical data are limited.
How serious is the interaction between Glyburide and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when nicardipine is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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