Drug interactions
Glyburide + Oxandrolone
Severity: Moderate
Glyburide and Oxandrolone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oxandrolone, an anabolic steroid, can lower blood glucose and increase insulin sensitivity, which may add to the effect of glyburide. Hypoglycemia risk is increased, especially in older patients.
What this interaction means in plain words
Glyburide and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering through anabolic steroid effects on insulin sensitivity and glucose metabolism.
What to do
Monitor blood glucose when oxandrolone is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Oxandrolone?
MediHelp rates the interaction as moderate. Glyburide and Oxandrolone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Oxandrolone, an anabolic steroid, can lower blood glucose and increase insulin sensitivity, which may add to the effect of glyburide. Hypoglycemia risk is increased, especially in older patients.
How serious is the interaction between Glyburide and Oxandrolone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when oxandrolone is started or stopped. Reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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