Drug interactions
Glyburide + Parecoxib
Severity: Minor
Glyburide and Parecoxib: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can potentiate sulfonylurea effects in some patients, and parecoxib (converted to valdecoxib) is a CYP2C9 substrate and weak inhibitor. Hypoglycemia is possible but the interaction is generally modest.
What this interaction means in plain words
Glyburide and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible competition for CYP2C9 metabolism and prostaglandin effects on insulin secretion; mechanism not firmly established.
What to do
Monitor blood glucose during short courses and review the glyburide dose if glucose falls. Teach patients hypoglycemia symptoms.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Parecoxib?
MediHelp rates the interaction as minor. Glyburide and Parecoxib have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. NSAIDs can potentiate sulfonylurea effects in some patients, and parecoxib (converted to valdecoxib) is a CYP2C9 substrate and weak inhibitor. Hypoglycemia is possible but the interaction is generally modest.
How serious is the interaction between Glyburide and Parecoxib?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose during short courses and review the glyburide dose if glucose falls. Teach patients hypoglycemia symptoms.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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