Drug interactions
Glyburide + Pindolol
Severity: Moderate
Glyburide and Pindolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Beta-blockers may impair recovery from hypoglycemia and mask adrenergic warning symptoms such as tremor and palpitations. Pindolol has intrinsic sympathomimetic activity, so the effect is somewhat less than with other nonselective agents, but sweating is still preserved and tachycardia may be blunted.
What this interaction means in plain words
Glyburide and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Beta-adrenergic blockade blunts the counter-regulatory response to hypoglycemia and masks its symptoms.
What to do
Monitor blood glucose more often and educate patients that sweating may be the main warning sign. Consider a cardioselective beta-blocker if clinically appropriate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Pindolol?
MediHelp rates the interaction as moderate. Glyburide and Pindolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Beta-blockers may impair recovery from hypoglycemia and mask adrenergic warning symptoms such as tremor and palpitations. Pindolol has intrinsic sympathomimetic activity, so the effect is somewhat less than with other nonselective agents, but sweating is still preserved and tachycardia may be blunted.
How serious is the interaction between Glyburide and Pindolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose more often and educate patients that sweating may be the main warning sign. Consider a cardioselective beta-blocker if clinically appropriate.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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