Drug interactions
Glyburide + Protriptyline
Severity: Minor
Glyburide and Protriptyline: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tricyclic antidepressants have occasionally been associated with altered glucose control, and in some patients they may enhance the glucose-lowering effect of sulfonylureas. Hypoglycemia may be more frequent or harder to recognize when both are used.
What this interaction means in plain words
Glyburide and Protriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive pharmacodynamic effect on glucose regulation; the mechanism is not well established.
What to do
Monitor blood glucose when protriptyline is started or stopped in a patient taking glyburide. Adjust the glyburide dose if glucose readings change.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Protriptyline?
MediHelp rates the interaction as minor. Glyburide and Protriptyline have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Tricyclic antidepressants have occasionally been associated with altered glucose control, and in some patients they may enhance the glucose-lowering effect of sulfonylureas. Hypoglycemia may be more frequent or harder to recognize when both are used.
How serious is the interaction between Glyburide and Protriptyline?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when protriptyline is started or stopped in a patient taking glyburide. Adjust the glyburide dose if glucose readings change.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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