Drug interactions
Glyburide + Salicylates
Severity: Moderate
Glyburide and Salicylates: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Salicylates, especially at higher doses, can lower blood glucose and may enhance sulfonylurea effect, leading to hypoglycemia. They may also displace sulfonylureas from protein binding.
What this interaction means in plain words
Glyburide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive glucose lowering and possible displacement of glyburide from plasma protein binding.
What to do
Monitor blood glucose when starting regular or high-dose salicylates and reduce the glyburide dose if hypoglycemia occurs. Low-dose use usually needs no change.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Salicylates?
MediHelp rates the interaction as moderate. Glyburide and Salicylates can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Salicylates, especially at higher doses, can lower blood glucose and may enhance sulfonylurea effect, leading to hypoglycemia. They may also displace sulfonylureas from protein binding.
How serious is the interaction between Glyburide and Salicylates?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting regular or high-dose salicylates and reduce the glyburide dose if hypoglycemia occurs. Low-dose use usually needs no change.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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