Drug interactions
Glyburide + Saquinavir
Severity: Moderate
Glyburide and Saquinavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the glycemic control achieved with glyburide. Glucose control may deteriorate after saquinavir is started.
What this interaction means in plain words
Glyburide and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Protease inhibitor-associated insulin resistance and impaired glucose metabolism opposes the glucose-lowering action of glyburide.
What to do
Monitor blood glucose after starting saquinavir and adjust the glyburide dose or antidiabetic regimen as required.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Saquinavir?
MediHelp rates the interaction as moderate. Glyburide and Saquinavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Protease inhibitors can cause insulin resistance and hyperglycemia, which may reduce the glycemic control achieved with glyburide. Glucose control may deteriorate after saquinavir is started.
How serious is the interaction between Glyburide and Saquinavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose after starting saquinavir and adjust the glyburide dose or antidiabetic regimen as required.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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