Drug interactions
Glyburide + Sodium citrate / citric acid
Severity: Minor
Glyburide and Sodium citrate / citric acid: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citrate-based alkalinizing agents raise gastric pH and could modify glyburide absorption, possibly strengthening its effect. The clinical significance is likely small.
What this interaction means in plain words
Glyburide and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Higher gastric pH may increase glyburide dissolution and absorption.
What to do
Monitor blood glucose if used regularly and separate dosing by about two hours.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Sodium citrate / citric acid?
MediHelp rates the interaction as minor. Glyburide and Sodium citrate / citric acid have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Citrate-based alkalinizing agents raise gastric pH and could modify glyburide absorption, possibly strengthening its effect. The clinical significance is likely small.
How serious is the interaction between Glyburide and Sodium citrate / citric acid?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose if used regularly and separate dosing by about two hours.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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