Drug interactions
Glyburide + Sulfamethoxypyridazine
Severity: Moderate
Glyburide and Sulfamethoxypyridazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfonamide antibacterials can enhance the effect of sulfonylureas and cause hypoglycemia. Sulfamethoxypyridazine is an older long-acting agent with limited data.
What this interaction means in plain words
Glyburide and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Likely CYP2C9 inhibition and protein-binding displacement, as with other sulfonamides.
What to do
Monitor blood glucose and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Sulfamethoxypyridazine?
MediHelp rates the interaction as moderate. Glyburide and Sulfamethoxypyridazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfonamide antibacterials can enhance the effect of sulfonylureas and cause hypoglycemia. Sulfamethoxypyridazine is an older long-acting agent with limited data.
How serious is the interaction between Glyburide and Sulfamethoxypyridazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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