Drug interactions
Glyburide + Sulfasalazine
Severity: Moderate
Glyburide and Sulfasalazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sulfasalazine may enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported in isolated cases. The interaction is uncommon and generally manageable.
What this interaction means in plain words
Glyburide and Sulfasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The mechanism is not established; sulfonamide-related effects on metabolism or protein binding may contribute.
What to do
Monitor blood glucose when sulfasalazine is started and reduce the glyburide dose if hypoglycemia occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Glyburide
- Bosentan + Glyburide Contraindicated
- Cholic acid + Glyburide Major
- Ciprofloxacin + Glyburide Major
- Clarithromycin + Glyburide Major
- Fluconazole + Glyburide Major
- Glyburide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Glyburide with Sulfasalazine?
MediHelp rates the interaction as moderate. Glyburide and Sulfasalazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sulfasalazine may enhance the glucose-lowering effect of sulfonylureas, and hypoglycemia has been reported in isolated cases. The interaction is uncommon and generally manageable.
How serious is the interaction between Glyburide and Sulfasalazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when sulfasalazine is started and reduce the glyburide dose if hypoglycemia occurs.
What other medicines interact with Glyburide?
MediHelp also lists interactions of Glyburide with, for example, Bosentan, Cholic acid, Ciprofloxacin. The full list is on the Glyburide page.
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